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Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans

Autoimmune thyroiditis and vitamin D

In a clinical trial including 2,605 people with heart failure but no prior history of diabetes, dapagliflozin (10 mg daily) led to a 32% reduction in new diabetes incidence over a median follow-up of 18 months (Barbarawi 2021

Here's the mechanism: the enzyme ALDH2 (aldehyde dehydrogenase 2) oxidises acetaldehyde into acetic acid, but this process requires adequate glutathione reserves to neutralise reactive oxygen species (ROS) generated during the reaction

Libraries were amplified in a final PCR step using barcoded TruSeq primers

Key Takeaway: Glutathione is the bodys primary internal defense system against oxidative stress and a vital component of natural liver detoxification